The cyber-physical security of any manufacturing system, specifically food and drug manufacturing, is essential. The technology in the pharmaceutical industry advanced significantly in last decade to improve upon every aspects of drug manufacturing. However, much less attention has been paid to identify and proactively mitigate the risk of cyber-physical attacks. Viruses that threaten these systems are very real and in recent years have proven very harmful and costly. Those that target drugs consumed by billions of people worldwide will inevitably have deadly consequences. Even with dedicated IT departments focused on determining cyber-physical attacks, it is imperative that a base layer of protection should be integrated into pharmaceutical manufacturing plants for the well-being of manufacturing system as well as consumers.